제   목 Immunoreactivity test of sperm against PLCZ1: effective diagnostic test for male infertility in art
등록일 2015/12/18 조회수 420 첨부파일
2012 European Society of Human Reproduction and Embryology

S.Y. Yoon, T.H. Kim, M.K. Kim, H.H. Seuk, D.R. Lee, T.K. Yoon

Abstract
Phospholipase C zeta 1 (PLCZ1), a strong candidate of egg activating sperm factor induces [Ca2+]i-oscillations in mammalian eggs that activate embryo development. Human sperm devoid PLCZ1 fails to induce [Ca2+]-oscillation in egg and lead to failure of egg activation and pregnancy. Here we produced human PLCZ1-specific antibody and evaluated the correlation of immunoreactivity of PLCZ1 in sperm and fertilization rate in ICSI patients.